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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B2
All Species:
16.67
Human Site:
S251
Identified Species:
33.33
UniProt:
P37059
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P37059
NP_002144.1
387
42785
S251
S
V
M
R
L
E
L
S
K
W
G
I
K
V
A
Chimpanzee
Pan troglodytes
XP_511130
387
42727
S251
S
V
M
R
L
E
L
S
K
W
G
I
K
V
A
Rhesus Macaque
Macaca mulatta
XP_001111794
386
41825
S250
S
V
M
R
I
E
L
S
K
W
G
I
K
V
V
Dog
Lupus familis
XP_546810
382
41989
S252
A
V
M
R
Q
E
L
S
K
W
G
V
K
V
S
Cat
Felis silvestris
Mouse
Mus musculus
P51658
381
41817
D252
T
I
I
R
Q
E
L
D
K
W
G
V
K
V
V
Rat
Rattus norvegicus
Q62730
381
41949
A252
A
V
I
R
Q
E
L
A
K
W
G
V
K
V
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508240
378
41961
S243
G
I
L
R
Q
E
L
S
R
W
G
V
K
V
V
Chicken
Gallus gallus
Q5ZJZ5
339
38218
C217
G
V
E
A
F
S
D
C
L
R
Y
E
M
Q
P
Frog
Xenopus laevis
NP_001086062
388
43271
M255
D
I
F
R
H
E
L
M
P
W
G
V
K
V
S
Zebra Danio
Brachydanio rerio
NP_997885
400
44225
D240
N
T
L
R
H
E
L
D
P
W
G
V
K
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y140
326
35725
R203
G
K
F
A
I
P
Q
R
A
A
Y
S
A
S
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130780
400
43694
L251
D
T
F
S
C
E
L
L
P
W
G
I
K
V
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
71.5
66.6
N.A.
59.1
61.2
N.A.
52.4
29.2
39.1
40.5
N.A.
22.7
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
81.1
77
N.A.
74.1
75.4
N.A.
67.6
45.9
55.1
57.5
N.A.
38.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
73.3
N.A.
53.3
60
N.A.
53.3
6.6
46.6
46.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
93.3
N.A.
80
86.6
N.A.
80
6.6
66.6
73.3
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
38.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
54
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
0
17
0
0
0
9
9
9
0
0
9
0
17
% A
% Cys:
0
0
0
0
9
0
0
9
0
0
0
0
0
0
0
% C
% Asp:
17
0
0
0
0
0
9
17
0
0
0
0
0
0
0
% D
% Glu:
0
0
9
0
0
84
0
0
0
0
0
9
0
0
0
% E
% Phe:
0
0
25
0
9
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
25
0
0
0
0
0
0
0
0
0
84
0
0
0
0
% G
% His:
0
0
0
0
17
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
25
17
0
17
0
0
0
0
0
0
34
0
0
0
% I
% Lys:
0
9
0
0
0
0
0
0
50
0
0
0
84
0
9
% K
% Leu:
0
0
17
0
17
0
84
9
9
0
0
0
0
0
0
% L
% Met:
0
0
34
0
0
0
0
9
0
0
0
0
9
0
0
% M
% Asn:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
9
0
0
25
0
0
0
0
0
9
% P
% Gln:
0
0
0
0
34
0
9
0
0
0
0
0
0
9
0
% Q
% Arg:
0
0
0
75
0
0
0
9
9
9
0
0
0
0
0
% R
% Ser:
25
0
0
9
0
9
0
42
0
0
0
9
0
9
34
% S
% Thr:
9
17
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
50
0
0
0
0
0
0
0
0
0
50
0
84
34
% V
% Trp:
0
0
0
0
0
0
0
0
0
84
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
17
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _